High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal-regulated kinase cascade

This study was undertaken to estimate the effect of dietary high oleic acid oil (OA) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in mice. Diet containing 10% oil was fed to mice through experimental periods. On day 30 after NNK injection (100 mg/kg body weight, i.p.), the treatment increased the level of prostaglandin E₂ (PGE₂) as well as proliferating cell nuclear antigen, a marker of cell proliferation in a high linoleic acid oil (LA)-fed group but not in an OA-fed group. The NNK treatment also induced the activation of an extracellular signal-regulated kinase (Erk) cascade (Erk, Mek and Raf-1) in an LA-fed group. On the other hand, OA feeding abolished the NNK-induced activation of the Erk cascade. In conjugation with these events, OA feeding reduced lung tumor incidence and tumor multiplicity (percentage of mice with tumors) in mice compared with LA feeding at the 20th experimental week. These results suggest that OA suppresses lung tumorigenesis and that this suppression is correlated with the inhibition of PGE₂ production and inactivation of the Erk cascade.     

Texture and Formation Mechanism of Fibrous Calcium Hydroxyapatite Particles Prepared by Decomposition of Calcium–EDTA Chelates

The texture of fibrous calcium hydroxyapatite (Ca₁₀-(PO₄)₆(OH)₂, CaHAP) particles that were prepared by the decomposition of calcium–ethylenediaminetetraacetic acid (calcium–EDTA) chelates at 100°C under various pH conditions (pH values of 5–10) was investigated by various means. Well-crystallized fibrous CaHAPs were produced at pH .6. The stoichiometry of the CaHAPs with a chemical formula of Ca_{10− x} (HPO₄) _x (PO₄)_{6− x} (OH)_{2− x} (H₂O) _x was improved by increasing the decomposition pH. All the CaHAPs had unit-cell dimensions of a = 0.9436 ± 0.0003 nm and c = 0.6881 ± 0.0006 nm, exhibiting an enlarged a value. The finding of mesoporosity of CaHAPs by nitrogen gas (N₂) adsorption measurement indicated that the CaHAPs were produced by an agglomeration of primary particles. Furthermore, the nonstoichiometric CaHAPs that formed at pH 6 developed ultramicropores, which were accessible to water (H₂O) molecules but not to N₂ molecules, by the elimination of H₂O molecules that were adsorbed in interstices of primary particles in less-orderly crystallized CaHAPs and/or by dehydration of HPO₄²⁻ groups. These findings by gas adsorption techniques could give evidence for the agglomeration mechanism to attain a polycrystalline CaHAP, although they exhibited good crystallinity with large size.     

Playful training with augmented reality games: case studies towards reality-oriented system design

In this paper, we propose a reality-oriented augmentation approach to support training activities. The approach aims at adding new value and playful features to traditional training environments with keeping their original look-and-feel. For example, a game monitoring service enables to automatically record game events so that players can review a gaming process and strategy for soul-searching, or replay most impressive scenes to share the experience with others after the game finishes. Even several services are running on background, digital devices and services are seamlessly integrated to the game environment in unobtrusive way so that players can concentrate on training as usual. The concept can be applied to both traditional games (e.g., poker and the game of Go) and non-gaming activities (e.g., calligraphy and drumming). We developed four case studies on the concept: Augmented Reality Go, EmoPoker, Augmented Calligraphy and AR Drum Kit. We discuss design issues in the reality-oriented augmentation process based on user study results.     

A portable toolkit for supporting end-user personalization and control in context-aware applications

A context-aware application in the pervasive computing environment provides intuitive user centric services using implicit context cues. Personalization and control are important issues for this class of application as they enable end-users to understand and configure the behavior of an application. However most development efforts for building context-aware applications focus on the sensor fusion and machine learning algorithms to generate and distribute context cues that drive the application with little emphasis on user-centric issues. We argue that, to elevate user experiences with context-aware applications, it is very important to address these personalization and control issues at the system interface level in parallel to context centric design. Towards this direction, we present Persona, a toolkit that provides support for extending context-aware applications with end-user personalization and control features. Specifically, Persona exposes a few application programming interfaces that abstract end-user customization and control mechanisms and enables developers to integrate these user-centric aspects with rest of the application seamlessly. There are two primary advantages of Persona. First, it can be used with various existing middlewares as a ready-to-use plug-in to build customizable and controllable context-aware applications. Second, existing context-aware applications can easily be augmented to provide end-user personalization and control support. In this paper, we discuss the design and implementation of Persona and demonstrate its usefulness through the development and augmentation of a range of common context-aware applications.     

Constant-phase-mode operation of the light-addressable potentiometric sensor

The constant-phase-mode operation of the light-addressable potentiometric sensor (LAPS) is proposed and demonstrated. In this new operation mode, the temporal change and the spatial distribution of the analyte concentration are recorded in the form of the bias voltage applied to the LAPS sensor plate, which is servo-controlled to maintain the phase of the photocurrent at a constant value with respect to the light modulation. The constant-phase-mode LAPS is advantageous for its wider measurement range and reduction of artifacts.     

A high-density multi-point LAPS set-up using a VCSEL array and FPGA control

A new LAPS (light-addressable potentiometric sensor) set-up will be introduced, in which the light sources are miniaturised by the utilisation of a VCSEL (vertical-cavity surface-emitting laser) array to increase the measurement spot density. An FPGA (field-programmable gate array) is used to generate modulation signals for individual illumination of each measurement spot of the LAPS. The new set-up can operate a large number of measurement spots simultaneously by reading out the sum photocurrent and separate the signals of the individual measurement spots by an FFT analysis. The frequency, amplitude and offset of the modulation signal can be configured for each measurement spot by software. The new system can be combined with a positioning stage allowing the parallel read out of a single line of measurement spots and a scan perpendicular to that line in a similar manner, like for an optical scanner set-up. First measurements demonstrate the functionality of the new LAPS set-up as a chemical imaging system.     

Plan for first phase of safety demonstration tests of the High Temperature Engineering Test Reactor (HTTR)

Safety demonstration tests using the High Temperature Engineering Test Reactor (HTTR) will be conducted for the purpose of demonstrating inherent safety features of High Temperature Gas-cooled Reactors (HTGRs) as well as providing the core and plant transient data for validation of HTGR safety analysis codes. The first phase safety demonstration test items include the reactivity insertion test and the coolant flow reduction test. In the reactivity insertion test, which is the control rod withdrawal test, one pair out of 16 pairs of control rods is withdrawn, simulating a reactivity insertion event. The coolant flow reduction test consists of the partial loss of coolant flow test and the gas circulators trip test. In the partial loss of coolant flow test, primary coolant flow rate is slightly reduced by control system. In the gas circulators trip test one and two out of three gas circulators are run down, simulating coolant flow reduction events. The gas circulators trip tests, in which position of control rods are kept unchanged, are simulation tests of anticipated transients without scram (ATWS).     

Novel screen technology for high‐contrast front‐projection display by controlling ambient‐light reflection

Abstract— One problem with front‐projection displays is that the screen contrast ratio decreases in bright ambient light. In this paper, we propose a new front‐projection display system that incorporates the control of reflection of ambient light in the screen design, providing a high contrast ratio even in a brightly lit room.